Nuclear transport of steroid hormone receptors

The principal assurance of safety in the transport of nuclear materials is the design of the packaging, which must allow for foreseeable accidents. The consignor bears primary responsibility for this as well as for the training of personnel directly involved in the transport. Many different radioactive materials are transported and the degree of potential hazard from these materials varies considerably. Conditions which packages are tested to withstand include: fire, impact, wetting, pressure, heat, and cold. Packages of radioactive material are checked prior to shipping and, when it is found to be necessary, cleaned to remove contamination.

TRNA export is also dependent on the various modifications it undergoes, thus preventing export of improperly functioning tRNA. This quality control mechanism is important due to tRNA's central role in translation, where it is involved in adding amino acids to a growing peptide chain. The tRNA exporter in vertebrates is called exportin-t . Exportin-t binds directly to its tRNA cargo in the nucleus, a process promoted by the presence of RanGTP. Mutations that affect tRNA's structure inhibit its ability to bind to exportin-t, and consequentially, to be exported, providing the cell with another quality control step. [7] As described above, once the complex has crossed the envelope it dissociates and releases the tRNA cargo into the cytosol.

Nuclear transport of steroid hormone receptors

nuclear transport of steroid hormone receptors

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nuclear transport of steroid hormone receptorsnuclear transport of steroid hormone receptorsnuclear transport of steroid hormone receptorsnuclear transport of steroid hormone receptorsnuclear transport of steroid hormone receptors

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