7-8 and then extracted with MTBE (70 ml_). The extract was washed with water (35 ml_) and concentrated in vacuo to give an oil. The oil was then dissolved in EOH (50 ml_) and treated with HOAc (10 ml_) and thiourea ( g, mmol). The mixture was heated at reflux overnight and then cooled to ambient temperature. The solids were filtered and washed with EtOH (10 ml_). The filtrate and the wash were combined and concentrated in vacuo, treated with MTBE (140 ml_) and washed successively with 10% aqueous Na 2 C0 3 and water. The mixture was concentrated in vacuo to give an oil. The oil was dissolved in MeCN (72 ml_), heated to -50 °C and then dibenzoyl-L-tartaric acid ( g, mmol) in acetonitrile (22 ml_) was added slowly. Seed crystals were added at -50 °C. The resultant slurry was stirred at 45-50 °C for 5 h, then cooled down to ambient temperature and stirred at ambient temperature overnight. The solids were filtered and washed with MeCN (2x 22 ml_). The wet cake was treated with MeCN (150 ml_) and heated to 50 °C. The slurry was stirred at 50 °C for 5 h, cooled over 1 h to ambient temperature and stirred at ambient temperature overnight. The solids were collected by filtration, washed with MeCN (2 x 20 ml_), dried under vacuum to give the title compound ( g, 34% overall yield, % purity, % ee) as a white solid. 1 H NMR (500 MHz, DMSO-d 6 ) δ ppm (m, 6H), 1 .13 (m, 4H), 1 .51 (m, 2H), 1 .58 (q, J – Hz, 2H), (s, 2H), (s, 3H), (s, 2H), (m, 2H), (m, 1 H), (m, 4H), (m, 2H), (m, 4H). EI-LCMS m/z 284 (M + +1 of free base).
I had fungal meningitis and was admitted to the hospital. When I was released, I ended up having a stroke and developed a brain aneurysm. I was readmitted, and I was there for almost another two months... I got very sick. I was vomiting all the time, had horrible headaches every day. I lost a good 30 pounds; I went down to 100 pounds... I missed about a year of work. And it was discovered later that I'd developed an abscess in my spinal cord. I had to have that surgically removed. But they could not get all of the abscess out, because they said if they would have sliced any deeper, they could have paralyzed me or I could have lost bowel or bladder function.
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